Hepatitis B Case Study: Lab Interpretation for New Grad NPs

Editor's note — August 2026: Hepatitis B screening recommendations have changed since this video was recorded. CDC now recommends one-time HBV screening for all adults ≥18 using the triple panel (HBsAg, anti-HBs, and total anti-HBc). Some details about distinguishing acute vs chronic infection and interpreting HBeAg/anti-HBe have also been updated. An updated version of this video is coming soon; see the updated Hepatitis B Screening & Lab Interpretation Cheat Sheet inside the Digital NP Binder for current guidance.

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Show notes:

Hepatitis B lab interpretation can feel like a total mind-bender. The lab names alone are like an alphabet soup!

Overall, there's a lot to say about Hepatitis B, but in this case study I'll be walking you through a case study of elevated liver enzymes, and how you'd approach testing for Hepatitis B.

Ordering and Interpreting Hepatitis B Labs

In this video you'll learn:

  • Which labs to order

  • What they mean

  • The next steps depending on your results, and when to refer to GI

Hepatitis B Labs Cheat Sheet

Looking for the Cheat Sheet? You can find it inside the Digital NP Binder.

Continue Learning: Lab Interpretation Series Bundle

If you liked this episode, it's a sneak preview of how we cover labs inside our comprehensive Lab Interpretation Series Bundle. It’s an ANCC-accredited CE bundle of courses that covers CBC, BMP, Renal Labs including Urinalysis, Dipstick & Microscopy, Microalbumin, TSH, and Hyperlipidemia in primary care! Check it out here.

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Hepatitis C Case Study: Lab Interpretation for New Grad NPs

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Head Injury Assessment in Primary Care for New Nurse Practitioners